Evolutionary interactions between haemagglutinin and neuraminidase in avian influenza
نویسندگان
چکیده
منابع مشابه
Cloning, Expression and Purification of Haemagglutinin and Neuraminidase gene of highly Pathogenic Avian Influenza H5N1 in Escherichia coli
The looming influenza virus pandemic requires simple and quicker vaccination strategies to prevent higher mortality and morbidity both in chickens and in humans. The process of current influenza vaccines manufacturing using embryonated eggs cannot help in controlling a future pandemic as it is too slow and the yield obtained by these methods are quit lower. In this study, we have developed a ba...
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Sixteen avian influenza (AI) H9N2 viruses were isolated from disease outbreaks in different parts of Iranduring (1998–2001). These AI isolates were used for pathogenicity, haemagglutinin (HA) gene variation andphylogenetic analysis. Results in both pathogenicity tests and HA gene cleavage site sequence detectionrepresented a non-highly pathogenic feature for all Iranian AI isolates studied. The...
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Continuing occurrences of human infections with avian influenza A (H5N1) viruses have ignited increasing fears that the next influenza pandemic is imminent. Fortunately, options for antiviral prophylaxis and treatment have been improved dramatically since the previous pandemics by the availability of neuraminidase inhibitors such as zanamivir and oseltamivir. However, although the prophylactic ...
متن کاملNeuraminidase gene sequence analysis of avian influenza H9N2 viruses isolated from Iran
Influenza A viruses possesses two virion surface glycoproteins including haemagglutinin (HA) and neuraminidase (NA). The NA plays an important role in viral replication and promotes virus release from infected cells and facilitates virus spread throughout the body. To find out any genomic changes that might be occurred on NA gene of avian influenza circulating viruses, we have genetically analy...
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There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 sw...
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ژورنال
عنوان ژورنال: BMC Evolutionary Biology
سال: 2013
ISSN: 1471-2148
DOI: 10.1186/1471-2148-13-222